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Tuesday, September 20, 2011

Online gamers crack AIDS enzyme puzzle


Online gamers have achieved a feat beyond the realm of Second Life or Dungeons and Dragons: they have deciphered the structure of an enzyme of an AIDS-like virus that had thwarted scientists for a decade.

The exploit is published on Sunday in the journal Nature Structural & Molecular Biology, where -- exceptionally in scientific publishing -- both gamers and researchers are honoured as co-authors.



Their target was a monomeric protease enzyme, a cutting agent in the complex molecular tailoring of retroviruses, a family that includes HIV.



Figuring out the structure of proteins is vital for understanding the causes of many diseases and developing drugs to block them.





But a microscope gives only a flat image of what to the outsider looks like a plate of one-dimensional scrunched-up spaghetti. Pharmacologists, though, need a 3-D picture that "unfolds" the molecule and rotates it in order to reveal potential targets for drugs.



This is where Foldit comes in.



Developed in 2008 by the University of Washington, it is a fun-for-purpose video game in which gamers, divided into competing groups, compete to unfold chains of amino acids -- the building blocks of proteins -- using a set of online tools.



To the astonishment of the scientists, the gamers produced an accurate model of the enzyme in just three weeks.



Cracking the enzyme "provides new insights for the design of antiretroviral drugs," says the study, referring to the lifeline medication against the human immunodeficiency virus (HIV).



It is believed to be the first time that gamers have resolved a long-standing scientific problem.



"We wanted to see if human intuition could succeed where automated methods had failed," Firas Khatib of the university's biochemistry lab said in a press release. "The ingenuity of game players is a formidable force that, if properly directed, can be used to solve a wide range of scientific problems."



One of Foldit's creators, Seth Cooper, explained why gamers had succeeded where computers had failed.



"People have spatial reasoning skills, something computers are not yet good at," he said.



"Games provide a framework for bringing together the strengths of computers and humans. The results in this week's paper show that gaming, science and computation can be combined to make advances that were not possible before."

Saturday, June 4, 2011

Attention!!?


I will try to keep my blog up to date after this..thanks for all of your comments regarding my blog..i will start to write new, exciting posts which is originally written by me..that is after SPM and mostly when i went into the university..thanks again for your support and comments..it have made me more excited to update my blog again..p/s: spread the words of my blog to your friends around the globe..

Saturday, January 15, 2011

Cerita Lucu : Masih Bayar

Anak : Ayah, kena bayar berapa wang mas kahwin kalau mau menikah?

Ayah : Sambil memperhatikan wajah anak lelakinya yang kecil itu.

Entahlah nak, kerana sampai sekarang Ayah masih lagi bayar kepada ibumu

Cerita Lucu : Tiga Kemungkinan

Malam menjelang ujian, seorang mahasiswa melempar undi dengan koin.

"Kalau muncul gambar, saya akan tidur; kalau angka, saya akan nonton teve.

Kalau koin ini bisa berdiri, saya akan belajar."

Cerita Lucu : Bahasa Inggeris

Ayah: Apasal B.I kamu nie asyik dapat kosong jer...! Apasal hah?
Anak: Eh, ayah! Tu bukan kosong. Tadi cikgu adik dah kasi bintang banyak kat bebudak lain. Ada dapat 5 bintang la, 4 bintang la. Bila giliran adik jer, bintang dah abis. Sebab tu cikgu bagi kat adik bulan.

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